The literature contains a series of foundational reviews covering the chemistry of cannabinoids that contextualize the advancement of the field. A crystallizable Δ 9-THC derivative was prepared in 1964, allowing ready access to the parent compound and ensuring that its structure and stereochemistry were correctly assigned (Gaoni and Mechoulam 1964), with CBD following soon after (Šantavý 1964). ![]() As recently as the late 1960s, it was considered that the active principles of cannabis were an unidentified mixture of tetrahydrocannabinols (Mechoulam 1970). In 1955, the first cannabinoid, cannabidiolic acid (CBDA), was isolated in a pure form by Krejčí and Šantavý. Δ 9-Tetrahydrocannabinol (THC), the primary psychoactive component, was first isolated as an impure resin in 1942, when the structure was proposed (Wollner et al. However, its chemical characterization history is far briefer. sativa is openly cultivated in more than 86 countries in Africa, the Americas, Asia, and Europe (United Nations Office on Drugs and Crime 2005), although the number is likely far higher. ![]() (Russo 2014) the Hindu Atharvaveda, composed between 15 B.C., where it is revered as a sacred plant for ritual and ceremony (Russo 2005) and in New Kingdom Egyptian texts dating to 1550 B.C. It is documented in Chinese texts since before 2000 B.C. sativa, see glossary) has been a staple of Eurasian culture.
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